Overview

Gallery Overview

Gallery Overview

1940s

Diluents

Diluents

Normal saline, half-strength saline, and sterile distilled water were prescibed as diluents for medications delivered by IPPB and small volume nebulizers.

Penicillin DPI

Penicillin DPI

Dr. Alvan Barach first reported on the administration of penicillin by inhalation in the early 1940s.

Penicillin G was the first agent administered as an inhaled dry powder. By the late 1940s, Abbott produced the Aerohaler which was designed to deliver penicillin G.

Image from Mark Sanders

Vaponefrin  (racemic epinephrine)

Vaponefrin (racemic epinephrine)

Vaponefrin was registered as a trademark in 1935.

Vapnefrin (racemic epinephrine) was nebulized and commonly administered in the treatment of upper airway edema and post-extrubation stridor.

1943 Patent

1943 Patent

The formulation of the drug that would be released as "Isuprel" was patented in 1943.

Isuprel

Isuprel

Isuprel (isoproterenol HCl) , was one of the first bronchodilators administered via IPPB.

Isuprel was trademarked in 1947.

Image from Felix Khusid

1940s Asthmanefrin ad

1940s Asthmanefrin ad

Image from Steve and Mary DeGenaro

1947 Adrenalin Kit

1947 Adrenalin Kit

Adrenalin 1:100

Image from Mark Sanders

1950s

Vaponefrin ad from 1950s

Vaponefrin ad from 1950s

Vaponefrin (Racemic epinephrine)

Image from Felix Khusid

Alevaire

Alevaire

Image from Felix Khusid

1955 Alevaire ad

1955 Alevaire ad

Alevaire, described as a mucolytic in this 1955 ad, was designed for both intermittent use via IPPB and continuous nebulization in tents.

1955 Alevaire article

1955 Alevaire article

The article "Alevaire as a Mucolytic Agent" by M.L. Tainter et al appeared in the November 3, 1955 issue of the New England Journal of Medicine.

Alevaire

Alevaire

In this 1956 ad, aerosolized Alevaire is recommended for the treatment of neonatal atelectasis.

Alcohol

Alcohol

In the early 1950s, diluted alcohol-water mixtures were nebulized and administered to patients with acute pulmonary edema. This practice continued into the 1970s.

1957 Rikers MDI ad

1957 Rikers MDI ad

Image from Hardluckasthmablogspot

Isuprel Mistometer

Isuprel Mistometer

Image from Felix Khusid

Isuprel Mistometer

Isuprel Mistometer

Image from Kerry George

1960s

S2

S2

Racemic epinephrine 2.25%

Trademarked 1962

Image from Kerry George

Micronefrin

Micronefrin

2.25% racemic epinephrine

Trademarked 1961

Image from Kerry George

1963 Mucomyst approved

1963 Mucomyst approved

Mucomyst (acetylcysteine) was introduced in 1963 and was offered in 10% and 20% solutions.

Vapo-N-Iso

Vapo-N-Iso

Vapo-N-Iso contained a 0.5% solution of isoproterenol HCl.

Trademarked 1963

Image from Felix Khusid

Bronkometer ad

Bronkometer ad

Bronkometer's original formula of isoetharine, phenylephrine, and thenyldiamine.

Image from Felix Khusid

Bronkometer

Bronkometer

Contains 10 mL of Dilabron (isoetharine ) mesylate 0.61% (w/w), phenylephrine HCl 0.125% (w/w) with saccharin, menthol, alcohol 30% (w/w) and with fluorochlorohydrocarbons as gaseous propellants. preserved with ascorbic acid 0.1% (w/w). Revised formula does not contain the antihistaminic Thenyldiamince HCl.

Image from Felix Khusid

Bronkometer

Bronkometer

Bronkometer 10 mL isoetharine mysylate and phenylephrine. This revised formula did not contain the antihistaminic Thenyldiamine HCl.

Image from Felix Khusid

Bronkosol

Bronkosol

Bronkosol was trademarked in 1966.
Isoetharine

Image from Kerry George

Bronkosol label

Bronkosol label

Image from Kerry George

Bronkosol label

Bronkosol label

Image from Kerry George

1970s

AsthmaNefrin MDI

AsthmaNefrin MDI

The AsthmaNefrin automatic aerosol canister indicates it contained 15 c.c. of racemic epinephrine.

Image from Felix Khusid

AsthmaNefrin

AsthmaNefrin

The box for AsthmaNefrin Aerosol Mist indicated that the refill contained 300 measured doses or 15 c.c. of racepinephrine.

Image from Felix Khusid

Bricanyl

Bricanyl

Bricanyl (terbutaline sulfate) was approved by the FDA in 1974.

Image from Robert Johnson

Bronkometer

Bronkometer

Breon's second revised formula for the Bronkometer contained Isoetharine mesylate 0.61% (W/W) contained saccharine, menthol, alcohol 30% (W/W), and with fluorochlorohydrocarbons as gaseous propelllants. Preserved with ascorbic acid 0.1% (W/W) Circa 1972

Image from Felix Khusid

Bronkometer

Bronkometer

Bronkometer (20 mL) bottle of Isoetharine mesylate

Image from Felix Khusid

Intal Spinhaler

Intal Spinhaler

Intal (cromolyn sodium) was introduced in the early 1970s

. A capsule containing a dry powder of the agent, was inserted into the delivery device called the Spinhaler. The capsule was pierced and the powder was released and delivered to the patient on inspiration.

Image from Kerry George

Intal Capsules and Spinhaler

Intal Capsules and Spinhaler

Image from Kerry George

Intal Spinhaler

Intal Spinhaler

The Spinhaler is shown disassembled with the Intal capsule in place.

Image from Kerry George

Spinhaler Whistles

Spinhaler Whistles

A whistle attachment could be added to the Spinhaler and would sound when correct breathing techniques was used.

Image from Kerry George

1980s

Brethaire

Brethaire

Brethaire (terbutaline sulfate) was supplied as an MDI. It was approved by the FDA in 1984.

Brethancer

Brethancer

The Brethancer was designed for use with the Brethaire MDI.

Image from Felix Khusid

Brethancer spacer

Brethancer spacer

In 1984, the Brethancer spacer by Geigy was marketed for use with the Brethaire (terbutaline) MDI.

Image from Felix Khusid

Ventolin

Ventolin

Allen and Hanbury's Ventolin (Albuterol sulfate) inhalation solution (0.5%)

Ventolin was approved by the FDA in 1987.

Image from Felix Khusid

Ventolin Rotahaler

Ventolin Rotahaler

Image from Wendy Dunlop

Ventolin Rotahaler

Ventolin Rotahaler

Image from Hardluck Asthma

Ventolin Unit Dose Kit

Ventolin Unit Dose Kit

The unit dose kit consisted of a Rotahaler and 24 Ventolin (albuterol sulfate) Rotacaps capsules.

Ventolin Rotocaps

Ventolin Rotocaps

Ventolin Rotacaps were approved by then FDA in 1988.

Image from Wendy Dunlop

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